The Wealth Index is based on a number of indicators of affluence including average household income and average net worth, but it also includes the value of material possessions and resources. It represents the wealth of the area relative to the national level. Values above or below 100 represent above-average wealth or below-average wealth compared to the national level.
| Name | County | Wealth Index | |
|---|---|---|---|
| 1. | Town of Kiawah Island | Charleston | 511 |
| 2. | Town of Seabrook Island | Charleston | 371 |
| 3. | Town of Sullivan's Island | Charleston | 322 |
| 4. | City of Isle of Palms | Charleston | 291 |
| 5. | Town of Briarcliffe Acres | Horry | 291 |
| 6. | Town of Hilton Head Island | Beaufort | 209 |
| 7. | Five Forks Census Designated Place | Greenville | 205 |
| 8. | Town of Edisto Beach | Colleton | 200 |
| 9. | City of Tega Cay | York | 198 |
| 10. | Coronaca Census Designated Place | Greenwood | 172 |
| 11. | Town of Mount Pleasant | Charleston | 172 |
| 12. | Riverview Census Designated Place | York | 167 |
| 13. | Lake Wylie Census Designated Place | York | 165 |
| 14. | Town of Rockville | Charleston | 163 |
| 15. | Lake Murray of Richland Census Designated Place | Richland | 161 |
| 16. | Mount Carmel Census Designated Place | McCormick | 160 |
| 17. | Willington Census Designated Place | McCormick | 158 |
| 18. | Town of Hollywood | Charleston | 157 |
| 19. | Town of James Island | Charleston | 156 |
| 20. | Pinopolis Census Designated Place | Berkeley | 149 |
